Oncogenes (frontiers in molecular biology series)

Oncogenes and the molecular biology of cancer

Gene transfer experiments have made it possible to detect active transforming sequences in the DNA of various human tumor cells. These sequences, the cellular oncogenes, have been found in tumors as diverse as neuroblastomas, leuke-mias, carcinomas, and sarcomas. They appear to represent molecular determinants that participate in transformation mechanisms that are common to a wide variety of tu...

New Frontiers for Organismal Biology

June 2013 / Vol. 63 No. 6 www.biosciencemag.org have generated extensive fundamental knowledge that now has us superbly positioned for “returning to the organism” (Stillman et al. 2011). The challenge is to extend, integrate, and exploit the insights from “outward” and “inward” gene-oriented biology to develop a deeper understanding of individual organisms’ higher-order emergent characteristics...

New frontiers in plant female reproductive biology

Frontiers of optofluidics in synthetic biology.

The development of optofluidic-based technology has ushered in a new era of lab-on-a-chip functionality, including miniaturization of biomedical devices, enhanced sensitivity for molecular detection, and multiplexing of optical measurements. While having great potential, optofluidic devices have only begun to be exploited in many biotechnological applications. Here, we highlight the potential o...

Tutorial in Molecular and Cellular Biology Cell Calcium, Oncogenes, and Hypertrophy

The cellular mechanisms of cardiac hypertrophy remain unclear despite tantalizing clues gleaned from a variety of experimental approaches. Here we examine the hypothesis that an increase in cytosolic free Ca concentration ([Ca],) triggers the expression of protooncogenes, which in turn direct the characteristic increase in protein synthesis. New results from perfused ferret hearts are presented...